Stuart MacFarlane, InBev's global director of customer standards, is to become president of InBev UK & Ireland.
MacFarlane takes over from Richard Evans who had been in the job for two years.
Evans was InBev's vice president of brands before taking on the UK and Ireland job and is a former marketing director of Interbrew UK.
Evans took over from Colin Pedrick who followed Steve Cahillane, who was promoted to chief commercial officer at InBev's headquarters in Belgium.
MacFarlane joined the company in 1992 and has held a number of senior roles in finance, sales, marketing and general management before taking up his current post.
He has also had stints at Rolls-Royce, Scottish & Newcastle and Whitbread.
MacFarlane starts his new role today.