A Health Committee Select Report is set to recommend introducing a minimum price of 50p a unit on alcoholic drinks.
The Committee issues a report on Friday and is set to argue that a minimum price on alcohol could save 3,000 lives a year.
"Ministers need to be looking at other solutions than what they are already looking at," chairman Kevin Barron told the Observer.
The MPs are also expected to call for curbs on alcohol advertising and sponsorship and criticise supermarkets for selling alcohol below cost.
However, Gordon Brown has previously voiced his concern over minimum pricing.
"We don't want the responsible, sensible majority of moderate drinkers to have to pay more or suffer as a result of the excesses of a minority," he said.