Zoe Rogers, who has run Enterprise Inns' lease the George Payne in Hove, East Sussex, since 2012, will operate Punch Taverns's site Whistlestop at Portslade train station as it stands until 1 January.
It will then be closed for “a couple of months” for a full refurbishment before opening again under its historic name of the Railway Inn.
Rogers said: “I felt that I had got the George Payne to where I wanted it to be and now was the time to move on to a fresh challenge. I approached Punch about the Whistlestop because I fell in love with it in exactly the same way as the George Payne."
She added: “There is so much potential there – there is a big kitchen that is under-used and the customer base is already there for a good pub selling decent food.
"There is also a big function room and with the location next to the train station and not many neighbours it is a perfect location for live music and comedy."