Greene King currently employs 39,000 people across the UK and runs 2,855 pubs, restaurants and hotels through brands such as Farmhouse Inns, Hungry Horse and Chef & Brewer.
Of the 100 jobs at risk, 60 are based at Greene King’s Bury St Edmonds site, in Suffolk, and a further 40 are based at their Burton-upon-Trent office, in Staffordshire.
In addition to vacancies already available, it’s understood that 25 new roles will also be created as part of the proposal.
A spokesperson for Greene King said: “The industry in which we operate is facing considerable cost pressures, and we are not immune.
“We need to focus on supporting our pubs and believe the proposed structure will deliver a simpler, more effective way of working and, at the same time, reduce costs.
“We are working hard to minimise the number of redundancies and are supporting any colleague who is at risk of redundancy by trying and find an alternative role in the business.
“This decision has not been taken lightly but is critical to ensure that Greene King is sustainable and fit for the future."
In April, The Morning Advertiser reported that Greene King’s like-for-like sales dropped by 1.8% in the 49 weeks to 8 April, with harsh weather conditions brought by the Beast from the East contributing to trading deficits.