The ale will go on sale today (10 June) and is available at its eponymous pubs in Bamber Bridge and Leyland, Lancashire, with the view to stimulate conversation about the upcoming EU referendum.
The Withy Arms Group CEO Lee Forshaw said: "The company remains impartial but we did a staff straw poll of 49 of the team regarding naming the beer either 'Remain' or 'Brexit'. and 'Brexit' came out on top.
"I will be voting for a Brexit also and I have commissioned a real ale in celebration of our independence day!"
Local MP Nigel Evans whose constituency includes Bamber Bridge where two of the group's pubs are based, said: "As president of the All Party Parliamentary Beer Group and a Brexiteer, I'm delighted that brewers have such common sense."
He added he hoped beer lovers and those wishing to leave to EU would unite to support the cause and enjoy having a "great pint" in the bargain.