Some 1,500 pubs participated in the event this year, which raised an estimated £190,000 for Prostate Cancer UK, The Morning Advertiser reported in July.
Organisers hope to exceed these numbers with the scheme’s fourth quiz and are encouraging pubs to sign up for the first time.
A guideline for when pubs should host their quiz is the week 3-7 March 2019, however, pubs can hold an event at any point in the year.
Des O'Flanagan, co-founder of PubAid, said he was thrilled to see new and returning pubs signing up.
He said: “We're grateful to our charity partner Prostate Cancer UK, which has made the event both easy to run for licensees and great fun for participants."
O'Flanagan added: "We're also grateful to all the pubs, brewers and pub groups who supported this year's quiz and we are confident even more will take part in 2019. It would be great to see more than 2,000 pubs run the quiz and raise more than £250,000 for charity.
"The quiz has become a tremendous showcase event for pub fundraising overall. Pubs raise an amazing £100m for charity every year, and we're pleased to see that message now getting through to consumers, MPs and others, helping to shape positive perceptions of the great British pub."
Prostate Cancer UK director of fundraising James Beeby said: "It's been really great to see the World's Biggest Pub Quiz grow since 2016 and we are excited to be PubAid's charity partner once again for 2019.
“We are extremely grateful to all the pubs who have taken part so far and raised an incredible amount of money for Prostate Cancer UK."
You can register your pub on the PubAid website to receive a free fundraising pack to help organise and host a quiz.