The pub group is increasing its range of drinks from the UK and non-EU producers across its 880-strong estate from Wednesday 26 September, which it says will result in lower prices for customers in its pubs.
Jagermeister and French brandies Courvoisier VS and Hennessy Fine de Cognac will no longer be served.
They will be replaced with American drink E&J Brandy, Australian brandy Black Bottle and Strika, a herbal liqueur produced in England.
E&J Brandy and Strika will be available in JDW pubs from 26 September, while Black Bottle will be available from the beginning of November.
JDW has already replaced Champagne with British and Australian sparkling wines as well as swapping German wheat beers with those from the UK.
The pub giant's founder and chairman Tim Martin said: “The three new products will be offered at a lower price than those they are replacing.
“This is a significant move by us and highlights our commitment to offering an excellent range of UK and world products, with an emphasis on quality and value for the 2m customers who visit our pubs each week."
Best choice and value
He added: “In blind tastings conducted by JDW, the new products were more popular than those they are replacing.
“We will continue to review all products over the next 24 months, with the object of making the business more competitive and offering the best choice and value for customers.
“Many commentators talk of a ‘cliff edge’ if the UK ‘crashes out’ of the EU without a deal. In reality, there is a no cliff edge, only sunlit uplands beyond the EU’s protectionist system of quotas and tariffs.
“All EU products have UK or non-EU replacements, often at equal or better quality and price. It is important to remember that 93% of the world is outside the EU.”