The group carried out a year-long fundraising campaign for the charity, which included family fun days, darts challenges and auctions held across its 130-site portfolio.
Its head office team completed a 100km continuous walk from Putney Bridge in west London to Henley in Oxfordshire, which raised £5,300.
Brakspear chief executive Tom Davies said: “This was our third estate-wide charity partnership and we’re delighted that our pub and head office teams have again risen to the challenge and thrown themselves into fundraising for Mind.”
Davies spoke of the importance of the cause, highlighting the fact that one in four people in the UK experience a mental health problem in any one year.
He added: “It's an issue that affects all of us, on both sides of the bar. We're very proud to have collected this sum, which will enable Mind to continue its life-changing work.”
Mind head of corporate partnerships Emma Ihsan said: "We are so grateful to Brakspear’s pub and head office teams for supporting Mind over the past year, and are delighted to receive this cheque.
“They have embraced all manner of fundraising activities, from the creative to the physically challenging, and have achieved a fantastic total. The money raised will help us to provide advice, information and support so that no one has to face their mental health problem alone.”
The brewer and operator gave a best fundraising award to the Unicorn pub in Kingwood near Henley, for its working in raising £2,010.
The site hosted a summer fare last May where many of its regulars baked items to sell and donated to a raffle.